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Cancer animal models are preclinical experimental systems used to study different aspects of cancer, including tumor development, progression, and response to treatment. Using animal models can gain important information about cancer and even the disease's underlying mechanisms. Alfa Cytology provides high-quality cancer animal model development services to help our clients with cancer vaccine development.
Fig. 1 Schematic of Xenograft cancer animal model.
Animal models of cancer have a variety of applications, including understanding cancer biology, evaluating the efficacy and toxicity of potential treatments, identifying biomarkers, and exploring drug resistance mechanisms. It is worth noting that during the preclinical development of cancer vaccines, the results of animal models provide important data for subsequent further development. These models are important tools for cancer research, helping to develop new therapies and advancing our understanding of this complex disease.
Cancer animal model is an important tool in cancer research. Usually, the use of animal models is highly correlated with the specific content of the experiment. The classification can be based on the type of animal, the type of cancer, and the specific type of experiment. Depending on research needs, Alfa Cytology provides diversified cancer animal model development services, including but not limited to the following.
| Type | Description |
| Syngeneic Mouse Model | The syngeneic tumor model is the oldest and most widely used preclinical model for evaluating anti-cancer therapies. Due to their complete immune function, they are particularly useful in evaluating tumor immunity, as they can be used to study the generation of de novo anti-tumor immune responses and do not require adoptive transfer of immune populations. |
| Xenograft Model | In xenotransplantation models, human cancer cells or tumor tissue is transplanted into an immunodeficient animal. Xenotransplantation offers a way to study tumor growth, metastasis, and treatment response in vivo. These models can also be further classified as subcutaneous xenografts or orthotopic xenografts. |
| Genetically Engineered Mouse Models (GEMM) | GEMM involves the manipulation of the mouse genome to create mice with genetic alterations that mimic specific aspects of human cancer. By introducing genetic mutations or deletions found in human tumors, it is possible to study tumor occurrence, progression, and response to intervention. |
| Carcinogen Induced Model | Carcinogen induction models involve exposing animals to specific chemicals, radiation, or environmental factors that can induce cancer. |
We have extensive experience in the field of cancer vaccine development.
We have advanced laboratory facilities and technology platforms.
We can provide customized solutions based on specific customer needs and project objectives.
We are committed to providing high-quality research results and reliable data support.
Our cancer animal models can accurately display relevant cancer features and provide accurate molecular and tumor data. Alfa Cytology is committed to the research and development of cancer vaccines, from the discovery of cancer antigens, and the development of different types of vaccines, to vaccine research for different cancer types, providing one-stop services. If you are interested in our service, please feel free to contact us for more information.