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Both non-degradable gold and silica particles can be used as effective delivery carriers. Some inorganic nanoparticles also showed some adjuvant effects. Because nanoparticles persist in tissue, the antigens they carry will induce a persistent immune response, providing an antigen library for sustained stimulation. Alfa Cytology provides high-quality inorganic nanoparticle delivery system development services to safeguard our clients' vaccine projects.
One of the main advantages of inorganic nanoparticles as a vaccine delivery system is their ability to enhance the stability, solubility, bioavailability, and targeting of the loaded substance. In addition, the loaded material can also be protected from degradation, ensuring controlled release. However, the use of inorganic nanoparticles also presents several challenges that need to be addressed urgently, including biosafety concerns, biocompatibility, potential toxic effects, and in vivo digestion. Biological interactions, immune responses, and long-term in vivo effects of inorganic nanoparticles need to be examined before use.
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The inorganic nanoparticle delivery system is the field of joint research and development of nanotechnology and materials science. Cancer vaccines use tiny particles made of inorganic materials, usually metals, metal oxides, or metal salts, as carriers to deliver antigenic peptides or nucleic acid substances to specific cells or tissues in the body. Targeting different customer needs, Alfa Cytology provides diversified inorganic nanoparticle delivery systems development services, including but not limited to the following.
Mesoporous Silica NPs Delivery Systems Development Service
Mesoporous silica nanoparticles (MSN) are a very promising platform for cancer vaccine materials due to their outstanding properties as delivery carriers, including adjustable pore structure, easily modified surface chemistry, and intrinsic biocompatibility.
Magnetic NPs Delivery Systems Development Service
Magnetic nanoparticles have been widely used in many biological fields, including cancer vaccines, because of their good biocompatibility, stable performance, easy surface modification, and magnetically controlled drug delivery, and release.
Metal-Organic Framework NPs Delivery Systems Development Service
Metal-organic framework materials (MOF), as a new generation of hybrid porous materials, have good biocompatibility, biodegradability, and size suitability, and have been widely used in cancer antigen delivery and other fields. In addition to the direct encapsulation of antigen peptides, whole-cell vaccines can also be encapsulated after functionalization. In addition, when combined with other therapies will also greatly improve the cancer cure rate, such as in combination with photodynamic therapy (PDT), can improve the solubility of photosensitizers, and synergistically improve cancer cure.
Gold NPs Delivery Systems Development Service
Gold nanoparticles (AuNP) can be used as nanocarriers for multivalent presentation of tumor-associated antigens. The advantages mainly include convenient preparation and easy control of particle size. More importantly, they can encapsulate a higher density of antigens than traditional carrier proteins.
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Inorganic nanoparticles can be designed to have specific properties, such as magnetic, optical, or catalytic properties, which further expand their potential applications. Alfa Cytology is committed to solving various problems in the field of cancer vaccines and has in-depth and extensive preclinical experience. If you are interested in our service, please feel free to contact us for more details.