Oil-based Delivery Systems Development Services
Oil-based delivery systems do not require the creation of emulsions, simplifying the use of vaccines. Alfa Cytology provides high-quality oil-based delivery system development services to help our clients with cancer vaccine development.
Introduction to Oil-based Delivery Systems
Oil emulsions are often used as a vaccine delivery platform, facilitating the slow release of antigens by forming a reservoir at the injection site. The antigens are trapped in the water phase and are passively released as the emulsion degrades in the body. However, oil-based delivery systems simplify vaccine administration by eliminating the need for emulsion formation.
Oil-based delivery systems can suspend vaccine components directly in the oil thinner, forcing immune cells to actively absorb formulation components without passive release. It can be custom-formulated using a mixture of CD8+ T-cell peptide epitopes, T-helper epitopes, and adjuvants of choice. Liposomes carry hydrophilic antigens and adjuvants directly into the oil medium, capturing all vaccine components in a form suitable for efficient uptake and processing/presentation by antigen-presenting cells (APCs).
Our Service
Oil-based delivery systems in cancer vaccines are a special type of vaccine formulation that has been developed to improve the effectiveness of cancer vaccines by enhancing antigen presentation, promoting immune cell activation, and prolonging the immune response. Targeting different customer needs, Alfa Cytology provides comprehensive oil-based delivery systems development services, including but not limited to the following.
Water-free Oil-based Delivery Systems
Development Service
There is no need to form an emulsion in a water-free oil-based formulation, as the formulation does not contain water-based ingredients. A strong and long-lasting T-cell immune response can be generated with cancer antigens.
- The antigens and adjuvants were prepared in liposomes.
- Lyophilized.
- Reconstructed directly in the oil before use.
The presence of lipids ensures that all ingredients in the formula are suspended in the oil. In combination with other forms of immunotherapy, the induced active immune response can be further enhanced.
Solid-in-Oil Delivery Systems
Development Service
Methods of coating proteins with surfactants have made enough progress, which successfully establish oil-in-solid (S/O) dispersion techniques. Oil-based dispersions containing proteins have the potential for a variety of applications.
- The low efficiency of macromolecule absorption can be overcome by oral and skin administration, and the convenience of administration is user-friendly.
- Compared with S/O delivery systems containing only tumor-associated antigen (TAA), co-delivery with immunomodulators enhances the anti-tumor immune response, inhibiting tumor growth and extending survival time in mice.
Our Advantages
We have extensive experience in the field of cancer vaccine development.
We have advanced laboratory facilities and technology platforms.
We can provide customized solutions based on specific customer needs and project objectives.
We are committed to providing high-quality research results and reliable data support.
Oil-based vaccine delivery system has a unique mechanism. Alfa Cytology is committed to developing all kinds of cancer vaccine delivery systems and has in-depth and extensive preclinical experience. If you are interested in our service, please feel free to contact us for more details.