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Polymer nanoparticles (NPs) are composed of biodegradable polymers and have shown promising applications in antigen-based vaccines due to their high antigen loading and enhanced antigen presentation efficiency. Alfa Cytology provides high-quality polymer nanoparticle delivery system development services, dedicated to the development of cancer vaccines.
Fig. 1 The schematic diagram of co-delivery systems.
Nanoparticles have a very high specific surface area and can be designed to be of specific size and charge to serve as carriers. Both synthetic polymers and natural polymers can be prepared into polymer nanoparticles through certain methods, each with its advantages. The following are two common types of polymer nanoparticles.
| Types | Description |
| Poly (lactic-co-glycolic acid) | PLGA-NP can encapsulate antigens and modify them with DC-specific antibodies and targeted parts. The modified PLGA-NP can better interact with the DC receptor, thereby increasing the uptake of NPs and promoting the maturation of DC. |
| Chitosan | Chitosan is a naturally occurring polysaccharide material that is biodegradable and non-toxic. It also showed immunostimulatory activities, such as increasing the accumulation and activation of macrophage cells, inhibiting tumor growth, and enhancing cytotoxic T lymphocyte response. |
Based on these widely used polymer materials and combined with our extensive experience in the field of cancer vaccines, Alfa Cytology provides diversified polymeric nanoparticle delivery systems development services, including but not limited to the following.
According to the differences in polymer sources, we have two main categories of delivery systems, i.e., synthetic polymeric NPs and natural polymeric NPs.
Synthetic Polymeric NPs Delivery Systems
PLGA is a polymer commonly used in the preparation of nanoparticles, and its protein or peptide compatibility can be improved by a series of chemical grafts. It shows good cytocompatibility in vitro, persists in lymph nodes, and promotes the expansion of T cells in vivo. In addition, many other cationic synthetic polymers have also been used in the development of nanoparticle delivery systems.
Natural Polymeric NPs Delivery Systems
Natural polymers, such as acetalized glucans (AcDEX), exhibit inherent adjuvant properties, reducing the need for co-delivery of adjuvants with antigens. Both the suspension and nanoparticles of chitosan showed immune-stimulating activity. Zinc-chitosan granules can effectively sensitize mice and guinea pigs, produce antigen-specific delayed hypersensitivity response, and effectively stimulate B and T lymphocytes.
According to the characteristics of NPs, our polymeric nanoparticle delivery systems include but are not limited to, the following two categories. In addition, we also provide customized services according to customer needs.
Pathogen-Like Polymeric NPs Development
A single polymer nanoparticle is still a hindrance in achieving effective cancer treatment effects, and different modifications will provide different biological significance. The modification of carbohydrates can simulate pathogens and greatly promote the effective capture of antigens by antigen-presenting cells in lymph nodes.
NPs-based Co-delivery Systems Development
Some adjuvants can cause serious adverse and long-lasting side effects in vivo, so carrier co-delivery peptide antigens and ligands are ideal alternatives. The therapeutic immune response generated by co-delivery nanoparticles works in concert with immune checkpoint blocking to lead to long-lasting immune memory of cancer.
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Polymer nanoparticles are widely used as delivery carriers in cancer vaccines, Alfa Cytology provides a variety of polymeric nanoparticle delivery systems development services and their preclinical services. If you are interested in our service, please feel free to contact us for more details.