Gastric (Stomach) Cancer
As one of the most common forms of solid tumors, stomach cancer has been recognized as the third leading cause of death worldwide. The symptoms of gastric cancer are usually not obvious, so it is difficult to detect at an early stage, and the therapy is not effective there is multiple drug resistance, and the prognosis is poor. Alfa Cytology is a world leader in the development of cancer vaccines. With our extensive experience and advanced platform, we can provide the best vaccine development services for gastric (stomach) cancer.
Introduction to Gastric (Stomach) Cancer
Stomach cancer is the sixth highest incidence in the world. Despite advances in therapy, the outlook for gastric cancer patients remains bleak.
New Immunotherapy for Gastric (Stomach) Cancer
Gastric cancer is a malignant disease with high incidence and high mortality. Therapy options for advanced gastric cancer, including chemotherapy and targeted therapy, are limited. Adaptive cell therapy, cancer vaccines, gene therapy, and monoclonal antibody therapy have all been used in therapies for gastric cancer with initial success.
Fig. 1 Different types of immunotherapies for advanced gastric cancer.
Gastric (Stomach) Cancer Vaccine
A new type of immunotherapy for advanced gastric cancer is a cancer vaccine, which activates the body's immune response against tumor cells. Proteins and peptides are commonly used antigens to trigger immune responses, but due to relatively weak immunogenicity, it is necessary to combine with adjuvants. In addition, mRNA cancer vaccines have also shown strong efficacy and moderate side effects, but they need to overcome the degradation problem during delivery. Here are some related solutions.
Gastric (Stomach) Cancer Vaccine with Different Adjuvants
There are a variety of adjuvants, most of which are closely related to immune activation in a variety of cancers. In addition, immunotherapy in combination with chemotherapy drugs is also an attractive cancer therapy that can effectively and selectively eliminate tumor-associated reversing immunosuppressive factors in the body. Here are some commonly used adjuvants.
- Aluminum Salts (Alum)
- Toll-like receptors (TLRs)
- Emulsions
- Bacteria
Gastric (Stomach) Cancer Vaccine with Various Delivery Systems
For the loading of vaccine active substances, and ensuring good biocompatibility and biodegradability, the selection of a suitable delivery system requires safety, control, and organism friendliness. In addition to antigenically active substances and adjuvants, immunoreactive cells such as dendritic cells (DC) and T cells also need to survive in them for a long time without loss of immune function. Here are some common delivery systems.
Our Service
Vaccines are playing a more and more important role in cancer therapy because of their targeted effectiveness and few side effects. Here are some methods that Alfa Cytology is working on to develop a targeted vaccine for gastric (stomach) cancer.
Cancer vaccine immunotherapy is a new cancer therapy method worth trying. Alfa Cytology is committed to the research and development of cancer vaccines, from the discovery of cancer antigens, and the development of different types of vaccines, to vaccine research for different cancer types, providing one-stop services. If you are interested in our service, please contact us.