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Liposomes are spherical nanovesicles formed by phospholipid bilayers. Phospholipids can self-assemble and form liposomes in water because they have hydrophilic heads and hydrophobic tails. They are a promising delivery platform due to their biocompatibility and widespread use in the vaccine field. Alfa Cytology provides high-quality liposome delivery system development services to safeguard our clients' vaccine projects.
The basic structure of liposomes consists of a lipid bilayer surrounding the water nucleus. The phospholipids that makeup liposomes can be natural or synthetic. Several key features of liposomes make them an attractive delivery system.
Biocompatibility and Biodegradability
Phospholipids are naturally occurring lipids in cell membranes. This makes liposomes composed of phospholipids biocompatible and biodegradable, minimizing the risk of toxicity or adverse reactions during in vivo administration.It’s very important for internal safety.
Versatile Substance
Encapsulation
Liposomes can encapsulate various substances, including hydrophilic and hydrophobic peptides and proteins, as well as nucleic acids. This versatility allows liposomes to serve as carriers for various therapeutic agents or immunogens in cancer vaccines.
Protection and Controlled
Release
The lipid bilayer forms a good barrier, protecting the contents from enzymatic degradation and improving the stability of the encapsulated payload. Control the release of therapeutic agents or antigens at the desired site and prolong the circulating half-life.
There are numerous classifications of cancer vaccines, and the development of their delivery systems also varies greatly. Targeting different customer needs, Alfa Cytology provides diversified liposome delivery systems development services. According to the difference in liposome modification, our lipid delivery systems include but are not limited to, the following two categories.
Mimicking Pathogens Liposomes Delivery Systems Development Service
Antigen-presenting cells are an essential part of the immune response. Therefore, the improvement of cancer vaccines can start from the antigen presentation stage. Loading physiological ligands or simulating pathogens on the surface of liposomes that can target antigen-presenting cells such as DC can achieve customized target cell delivery.
Liposomes Magnetic Delivery Systems Development Service
The biggest advantage of therapeutic cancer vaccines is to enhance antigen-specific immunity against tumors. However, insufficient T cell activation and immune tolerance make the effect mediocre. Active targeting of lymph nodes through magnetic delivery of loaded antigen magnetic liposomes. Significant accumulation will occur at the target location, ultimately leading to an increase in the number of active DCs in lymph nodes and an increase in cytotoxic T lymphocytes (CTLs) within the tumor, which are associated with effective tumor growth inhibition.
From an application point of view, we develop liposome delivery systems that can be used in nucleic acid and peptide vaccines. In addition, we also provide customized services according to customer needs.
Nucleic Acid-Loaded Liposomes Delivery Systems Development Service
Unlike peptides or proteins, nucleic acids have immunogenicity and do not require adjuvants. However, it is necessary to cross the cell membrane or nuclear membrane, and an effective delivery system is needed. Liposome encapsulation of nucleic acids mainly relies on electrostatic interactions. The negatively charged nucleic acid is wrapped on the surface of the bilayer lipid particles, and it undergoes electrostatic interaction with the newly positively charged bilayer lipid particles. Finally, multiple layers of particles are formed, where nucleic acid is captured between the two layers of lipid particles.
Peptide-Loaded Liposomes Delivery Systems Development Service
Peptide antigens have poor immunogenicity, and liposomes can serve as co-delivery systems for multiple substances. Liposomes can load different substances, so in addition to delivering antigen peptides, they can also load adjuvants, inhibitors, etc., while increasing the immunogenicity of peptide antigens and blocking immune checkpoints.
Professional
technical team.
Advanced experimental equipment.
Empowering success through cooperation.
Strict quality control system.
Liposomes are composed of biocompatible materials and have good safety, making them widely used in cancer vaccines which contain peptide vaccines and nucleic acid vaccines. Alfa Cytology is committed to solving various problems in the field of cancer vaccines and has in-depth and extensive preclinical experience. If you are interested in our service, please feel free to contact us for more details.
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