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Skin cancer, abnormal growth of skin cells, is most commonly seen on skin exposed to the sun. Alfa Cytology is a world leader in the development of cancer vaccines. With our extensive experience and advanced platform, we can provide the best vaccine development services for skin cancer.
The risk of skin cancer can be reduced by limiting or avoiding ultraviolet (UV) radiation. Checking the skin for suspicious changes can help detect skin cancer as early as possible, and early detection can greatly increase the likelihood of successful therapy. There are four main types of skin cancer.
During tumor development, cancer cells undergo many molecular changes. Identifying specific molecular changes could help develop more effective targeted therapies.
Of all tumor types, skin cancer is extremely sensitive to immunotherapy. Unique immunogenicity makes skin cancer a poster child for tumor immune interactions driven by high mutation load, overexpression of tumor antigens, and/or viral antigens. However, the mechanism of drug resistance is complex, including the influence of intrinsic factors of tumor cells, T cells, and microenvironment factors.
Fig. 1 Immune mechanisms in skin cancers. (Farhana, A., 2023)
The growing understanding of immune surveillance and tumor escape is providing us with new perspectives in the field of immunotherapy. Antigen-synthesis-based antitumor vaccines that elicit an immune response through antigen-presenting cells (APC) are an effective and safe immunotherapy. Cancer vaccines can be divided into the following categories according to different ways of classification.
| By Types of Vaccines | By Types of Administration | By Types of Vectors |
|---|---|---|
| Peptide Vaccine | Injection | Solid-in-Oil Nanocarriers |
| mRNA Vaccine | Skin patch | Micellar Antigen Carrier |
Therapeutic cancer vaccines are an emerging approach that has the potential to turn on T cells by activating regional lymph nodes and antigen presentation in the tumor microenvironment. As a result, immune cells are preconditioned and awakened to attack the tumor. Clinical trials of many skin cancer vaccines are underway. Vaccine targets include tumor-associated antigens, tumor-specific antigens, oncolytic viruses, and toll-like receptors.
Although targeting APCs with antigens is the most important hypothesis for vaccine development, immunogenicity needs to be improved in some ways. These include the synthesis of modified peptide antigens and the use of adjuvants and delivery systems. Therefore, against skin cancer, Alfa Cytology provides various services related to cancer vaccine development, including antigen recognition services, adjuvant and delivery system development services, and vaccine preclinical testing services.
The use of therapeutic cancer vaccines is one of the important new strategies for treating cancers, including skin cancer. Alfa Cytology is committed to the research and development of therapeutic skin cancer vaccines, from the discovery of cancer antigens, and the development of different types of vaccines, to vaccine research for different cancer types, providing one-stop services. If you are interested in our service, please get in touch with us.
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